Effect of Acupoint 830 nm Laser Irradiation on Skeletal Muscle SOD and MDA Contents in Exhaustive Exercise Rats / 上海针灸杂志

Objective To investigate the effect of acupoint 830 nm semiconductor laser irradiation on skeletal muscle SOD and MDA contents in exhaustive exercise rats.Methods Rats did exhaustive eccentric exercise by downhill treadmill running. Rats were randomized into a blank group (group A), a model group (group B), a pre-exercise semiconductor laser pre-irradiation group (group C), a post-exercise laser irradiation group (group D) and a pre- and post-exercise laser irradiation combination group (group E). Except the blank group, each of the other groups was again divided into 24 h and 48 h subgroups, and there were groups B1, B2, C1, C2, D1, D2, E1 and E2, 8 rats each. Group B rats did one exhaustive exercise by treadmill running. Group C rats received laser pre-irradiation for 7 days before they did exhaustive exercise. Group D rats received laser irradiation after the exercise. Group E rats received laser pre-irradiation for 7 days before treadmill running and combined laser irradiation after the exercise. Specimens were taken in groups B1, C1, D1 and E1 at 24 h after the exercise and in groups B2, C2, D2 and E2 at 48 h after the exercise. A 830 nm semiconductor laser transmitter was used for laser irradiation. Point Chengshan was selected in the rats. Skeletal muscle superoxide dismutase (SOD) and malondialdehyde (MDA) contents were measured in every group before and after treatment.Results There was a statistically significant difference in muscular MDA content between group B1, D1, B2 or C2 and group A (P<0.05) and between group D2 or E2 and group B2 (P<0.05). There was a statistically significant difference in muscular SOD content between group B1, C1, D1 or B2 and group A (P<0.05) and between group C2, D2 or E2 and group B2 (P<0.05).Conclusion Acupoint 830 nm semiconductor laser irradiation can restore unbalanced oxidation-reduction reactions.

Overview of Mechanical Research on Basic Acupuncture Manipulation / 上海针灸杂志

Acupuncture mechanics in acupuncture manipulation of traditional Chinese medicine is important information for elucidating the essence of acupuncture manipulation and clinically observed acupuncture effects and has some morphological, histochemical and biochemical effects on fibroblasts and cytoskeletons in the tissue. This article generalizes from the present newest research advances, which is of important significance for revealing the mechanism of the therapeutic effect of acupuncture.

Influence of gingko extract on metabolism of simvastatin / 中国中药杂志

<p><b>OBJECTIVE</b>To conclude the possible interaction between gingko extract and simvastatin, by studing the effect of gingko extract on vitro metabolism of simvastatin and involving critical metabolic enzyme, which can guide the clinicians to use them rationally (propose good guideline for rational using of the two medicine mentioned above).</p><p><b>METHOD</b>Thirty-two female SD rats were randomly separated into 4 groups, including negative control group. High dose of gingko extract. Low dose of gingko extract and positive control group. All groups were administered for 10 days with stomach tube, and then the quantity of liver microsome protein, the activity of CYP3A were determined by spectrophotograph simvastatin was incubated with the liver microsome, and the effect of gingko extract on its metabolism was estimated by measuring the amount of simvastatin by HPLC.</p><p><b>RESULT</b>Comparing with the negative contrast group: the quantity of liver microsome protein, the activity of CYP3A and the metabolism of simvastatin in positive control group were all increased markly (P < 0.05). In high dose group, the quantity of liver microsome protein and the activity of CYP3A were both increased significantly (P < 0.05), and the metabolism of simvastatin also accelerate obviously (P < 0.05). But in the low dose group significant distinction of every index was not found.</p><p><b>CONCLUSION</b>High dose of gingko extract can induce the activity of CYP3A, and promote the metabolism of simvastatin, so the medical interaction should be focused when gingko extract is coadministered with simvastatin and other substracts of CYP3A.</p>

Comparative observation on CHD TCM patterns,syndrome of spleen deficiency with/or phlegm turbidity and coronary lesion / 中华中医药杂志

Objective:To observe the relationship between coronary heart disease(CHD)patterns and coronary lesion,and between the syndrome of spleen deficience with/or phlegm turbidity(SP)and coronary lesion.Methods:Traditional Chinese medicine(TCM)patterns and syndromes of 81 patients with CHD confirmed by coronary angiography(CAG)were differentiated.And the relationship between CHD patterns and coronary lesion,and between SP syndrome and coronary lesion were analyzed.The extent of coronary lesion was reflected by the affected branches and degree of arterial constriction based on CAG.Results:In 81 cases,the average affected branches amount in the group of blood stasis pattern was the most;arterial constriction degree in the group of cold-accumulation pattern was the most severe;the coronary lesion of cases in the qi-stagnation pattern group and yin-deficiency pattern group were slighter;but there was not significant difference among the CHD patterns groups.In 81 cases,there was significant difference between the SP syndrome group(38 cases)and the non-SP syndrome group(43 cases)in both affected branch distribution and arterial constriction degree.It manifested that the left circumflex artery(LCX)and right coronary artery(RCA)was easier to be affected and their constriction was more severe in the SP syndrome group.Conclusion:There was relationship between different CHD patterns and coronary lesion;coronary lesion and the clinical symptom of SP syndrome may exist the relationship of cause and effect.